MovDisordV3, Main, Exploration, bibRecord, 001017

Progression of Cortical Thinning in Early Parkinson's Disease

Identifieur interne : 001017 ( Main/Exploration ); précédent : 001016; suivant : 001018

Progression of Cortical Thinning in Early Parkinson's Disease

Auteurs : Naroa Ibarretxe-Bilbao [Espagne] ; Carme Junque [Espagne] ; Barbara Segura [Espagne] ; Hugo C. Baggio [Espagne] ; Maria J. Marti [Espagne] ; Francesc Valldeoriola [Espagne] ; Nuria Bargallo [Espagne] ; Eduardo Tolosa [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:13-0063588

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Cognition.

English descriptors

KwdEn :
- Cognition, Nervous system diseases, Parkinson disease.

Abstract

The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.

Affiliations:

Espagne

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Curation: 002D00
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Le document en format XML

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<author><name sortKey="Baggio, Hugo C" sort="Baggio, Hugo C" uniqKey="Baggio H" first="Hugo C." last="Baggio">Hugo C. Baggio</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clinic de Barcelona</s1>
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<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biomedical Research August Pi i Sunyer</s1>
<s2>Catalonia</s2>
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<country>Espagne</country>
<wicri:noRegion>Institute of Biomedical Research August Pi i Sunyer</wicri:noRegion>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry and Clinical Psychobiology, University of Barcelona</s1>
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<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
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</author>
<author><name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="Maria J." last="Marti">Maria J. Marti</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clinic de Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
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<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biomedical Research August Pi i Sunyer</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
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<country>Espagne</country>
<wicri:noRegion>Institute of Biomedical Research August Pi i Sunyer</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clinic de Neurociències, Hospital Clinic de Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
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<country>Espagne</country>
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</author>
<author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clinic de Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
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<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biomedical Research August Pi i Sunyer</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clinic de Neurociències, Hospital Clinic de Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
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<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biomedical Research August Pi i Sunyer</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
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<country>Espagne</country>
<wicri:noRegion>Institute of Biomedical Research August Pi i Sunyer</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre de Diagnostic per la Imatge Hospital Clinic de Barcelona, Hospital Clinic de Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clinic de Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biomedical Research August Pi i Sunyer</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Institute of Biomedical Research August Pi i Sunyer</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clinic de Neurociències, Hospital Clinic de Barcelona</s1>
<s2>Catalonia</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Cognition</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name>
</noRegion>
<name sortKey="Baggio, Hugo C" sort="Baggio, Hugo C" uniqKey="Baggio H" first="Hugo C." last="Baggio">Hugo C. Baggio</name>
<name sortKey="Baggio, Hugo C" sort="Baggio, Hugo C" uniqKey="Baggio H" first="Hugo C." last="Baggio">Hugo C. Baggio</name>
<name sortKey="Baggio, Hugo C" sort="Baggio, Hugo C" uniqKey="Baggio H" first="Hugo C." last="Baggio">Hugo C. Baggio</name>
<name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name>
<name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name>
<name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name>
<name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name>
<name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name>
<name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name>
<name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name>
<name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name>
<name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="Maria J." last="Marti">Maria J. Marti</name>
<name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="Maria J." last="Marti">Maria J. Marti</name>
<name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="Maria J." last="Marti">Maria J. Marti</name>
<name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Barbara" last="Segura">Barbara Segura</name>
<name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Barbara" last="Segura">Barbara Segura</name>
<name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Barbara" last="Segura">Barbara Segura</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Progression of Cortical Thinning in Early Parkinson's Disease

Progression of Cortical Thinning in Early Parkinson's Disease

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